The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels.

Abstract excerpt

Slo2 Na(+)-activated potassium channels are widely expressed in neurons and other cells, such as kidney, heart, and skeletal muscle. Although their important physiological roles continue to be appreciated, molecular determinants responsible for sensing intracellular Na(+) remain unknown. Here we report identification of an Na(+) regulatory site, similar to an Na(+) coordination motif described in Kir channels,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biophysical Phenomena
• Share to Chlorides