Article
Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels.
FEBS letters - 9 Feb 2001
Soom M, Schönherr R, Kubo Y, Kirsch C, Klinger R, Heinemann S H
Abstract excerpt
Inwardly rectifying potassium channels require binding of phosphatidylinositol-4,5-bisphosphate (PIP2) for channel activity. Three independent sites (aa 175-206, aa 207-246, aa 324-365) were located in the C-terminal domain of Kir2.1 channels by assaying the binding of overlapping fragments to PIP2 containing liposomes. Mutations in the first site, which abolished channel activity, reduced PIP2 binding of this...
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