Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs.

doi:10.1016/j.jaut.2016.01.002

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Article

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs.

Journal of autoimmunity - 1 Apr 2016

Ricaño-Ponce Isis, Zhernakova Daria V, Deelen Patrick, Luo Oscar, Li Xingwang, Isaacs Aaron, Karjalainen Juha, Di Tommaso Jennifer, Borek Zuzanna Agnieszka, Zorro Maria M, Gutierrez-Achury Javier, Uitterlinden Andre G, Hofman Albert, van Meurs Joyce, Netea Mihai G, Jonkers Iris H, Withoff Sebo, van Duijn Cornelia M, Li Yang, Ruan Yijun, Franke Lude, Wijmenga Cisca, Kumar Vinod

Abstract excerpt

Genome-wide association and fine-mapping studies in 14 autoimmune diseases (AID) have implicated more than 250 loci in one or more of these diseases. As more than 90% of AID-associated SNPs are intergenic or intronic, pinpointing the causal genes is challenging. We performed a systematic analysis to link 460 SNPs that are associated with 14 AID to causal genes using transcriptomic data from 629 blood samples. We...

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PMID: 26898941
DOI: 10.1016/j.jaut.2016.01.002
PMCID: PMC5391837

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