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Article

Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1.

Journal of inorganic biochemistry - 1 Feb 2010

Chen Lei, Feng Yu, Zhou Yinqiu, Zhu Weiliang, Shen Xu, Chen Kaixian, Jiang Hualiang, Liu Dongxiang

Abstract excerpt

Zn(2+) directly participates in catalysis of histone deacetylase (HDAC) Classes I, II, IV enzymes while its role in HDAC Class III activity is not well established. Herein we investigated the effects of Zn(2+) on the deacetylase activity of sirtuin 1 (silent mating type information regulation 2 h...

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Source

Identifiers

PMID: 19923004
DOI: 10.1016/j.jinorgbio.2009.10.021

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19923004-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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