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Regulation of Histone Deacetylase 3 by Metal Cations and 10-Hydroxy-2E-DecenoicAcid: Possible Molecular Epigenetic Mechanisms of Queen-Worker Bee Differentiation

2018-09-12

Abstract excerpt

Histone deacetylases (HDACs) catalyze the hydrolysis of ε-acetyl-lysine residues of histones. Removal of acetyl groups results in condensation of chromatin structure and repression of gene expression. Human class I, II, and IV HDACs are said to be zinc-dependent in that they require divalent zinc ions to catalyze the deacetylase reaction. HDACs are considered potential targets for the treatment of cancer due to th...

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Literature Corpus work: 7d28ede9-eded-5f40-b5ab-6da7e247558f
DOI: 10.1101/415364

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