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Cellular zinc status alters chromatin accessibility and binding of transcription factor p53 to genomic sites

2023-11-21

Abstract excerpt

Zinc (Zn 2+ ) is an essential metal required by approximately 2500 proteins. Nearly half of these proteins act on DNA, including > 850 human transcription factors, polymerases, DNA damage response factors, and proteins involved in chromatin architecture. How these proteins acquire their essential Zn 2+ cofactor and whether they are sensitive to changes in the labile Zn 2+ pool in cells remain open questions. He...

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Identifiers and source

Literature Corpus work
cac119db-6b21-52a8-bbb4-f602ab3b3923
DOI
10.1101/2023.11.20.567954
Open publication

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Cellular zinc status alters chromatin accessibility and binding of transcription factor p53 to genomic sitesDOI 10.1101/2023.11.20.567954
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