Article

Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding Groups

2025-03-31

Abstract excerpt

Histone deacetylases (HDACs) are key regulators of gene expression, influencing chromatin remodeling and playing a crucial role in various physiological and pathological processes. Aberrant HDAC activity has been linked to cancer, neurodegenerative disorders, and inflammatory diseases, making these enzymes attractive therapeutic targets. HDAC inhibitors (HDACis) have gained significant attention, particularly thos...

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Literature Corpus work: 2ddeb0b1-914b-50fb-a957-7a14d223906a
DOI: 10.20944/preprints202503.2208.v1

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