Sirtuins as pharmacological targets in neurodegenerative and neuropsychiatric disorders

Abstract excerpt

Histone deacetylases (HDACs) are enzymes that regulate several processes, such as transcription, cell proliferation, differentiation and development. HDACs are classified as either Zn2+‐dependent or NAD+‐dependent enzymes. Over the years, experimental and clinical evidence has demonstrated that HDAC modulation is a critical process in neurodegenerative and psychiatric disorders. Nevertheless, most of the studies...

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• Autophagy in Disease and Therapy
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