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Article

Lack of association between TLR4 Asp299Gly polymorphism and atherosclerosis: evidence from meta-analysis.

Thrombosis research - 1 Oct 2012

Zhang Kui, Zhang Lushun, Zhou Bin, Wang Yanyun, Song Yaping, Rao Li, Zhang Lin

Abstract excerpt

INTRODUCTION: Toll like receptor 4 (TLR4) expression was found to increase markedly in human atherosclerotic lesions, notably on macrophages and endothelial cells. TLR4 Asp299Gly polymorphism was associated with a blunted receptor activity and a subsequently diminished inflammatory response, and may subsequently reduce atherosclerosis (AS) risk. However, the results of molecular epidemiological studies remained...

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Identifiers

PMID: 22857799
DOI: 10.1016/j.thromres.2012.07.008

Genes

TLR4

Provenance

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