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Article

A PI3 kinase inhibitor found to activate bestrophin 3.

Journal of cardiovascular pharmacology - 1 Jan 2010

Qu Zhiqiang, Han Xiaohua, Cui Yuanyuan, Li Chunlin

Abstract excerpt

Bestrophin 3 (Best3), a member of bestrophin Cl channel family, is a CaCl(cGMP) channel candidate in vascular smooth muscle cells. The mechanism for its activation remains unclear. In previous studies, we reported that an autoinhibitory domain ((356)IPSFLGS(362)) existed in Best3 C-terminus and when the autoinhibitory domain was mutated, the Best3 channel was dramatically activated. In this study, we further...

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Identifiers

PMID: 19920768
DOI: 10.1097/FJC.0b013e3181c87c85
PMCID: PMC3052421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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