Article
A short motif in the C-terminus of mouse bestrophin 3 [corrected] inhibits its activation as a Cl channel.
FEBS letters - 3 Apr 2006
Qu Zhiqiang, Cui Yuanyuan, Hartzell Criss
Abstract excerpt
Bestrophins are a new family of anion channels. Here, we examined the Cl channel activity of mBest4. Surprisingly, wild type mouse bestrophin-4 (mBest4) did not induce functional Cl channels when over-expressed in HEK293 cells. However, deletion of part of the C-terminus (residues 353-669) produced large Cl currents, suggesting the presence of a C-terminal motif that inhibited Cl channel function. Deletion of a...
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