Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities.

doi:10.1128/mcb.12.1.82-88.1992

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Article

Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities.

Molecular and cellular biology - 1 Jan 1992

Werner S, Duan D S, de Vries C, Peters K G, Johnson D E, Williams L T

Abstract excerpt

We have cloned a genomic region of the murine fibroblast growth factor (FGF) receptor 1 (FGFR1) gene that includes three alternative exons for the third immunoglobulinlike domain in the extracellular region of the receptor. The mRNA of one of these splice variants encodes a secreted receptor that...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Cells, Cultured
Cloning, Molecular
DNA
Fibroblast Growth Factors
Genetic Variation
Humans
Ligands
Mice
Mice, Inbred BALB C
Molecular Sequence Data

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing

Receptors, Cell Surface

Receptors, Fibroblast Growth Factor

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 1309595
DOI: 10.1128/mcb.12.1.82-88.1992
PMCID: PMC364071

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1309595-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.