Article
Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.
Current genetics - 1 Jul 2005
Tsutsui Yasuhiro, Morishita Takashi, Natsume Toyoaki, Yamashita Kentaro, Iwasaki Hiroshi, Yamao Fumiaki, Shinagawa Hideo
Abstract excerpt
Schizosaccharomyces pombe rad2 is involved in Okazaki fragments processing during lagging-strand DNA replication. Previous studies identified several slr mutants that are co-lethal with rad2Delta and sensitive to methyl methanesulfonate as single mutants. One of these mutants, slr3-1, is characterized here. Complementation and sequence analyses show that slr3-1 (mcl1-101) is allelic to mcl1(+), which is required...
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