Article
Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair.
Genetics - 1 Apr 2004
Schürer K Anke, Rudolph Christian, Ulrich Helle D, Kramer Wilfried
Abstract excerpt
The MPH1 gene from Saccharomyces cerevisiae, encoding a member of the DEAH family of proteins, had been identified by virtue of the spontaneous mutator phenotype of respective deletion mutants. Genetic analysis suggested that MPH1 functions in a previously uncharacterized DNA repair pathway that protects the cells from damage-induced mutations. We have now analyzed genetic interactions of mph1 with a variety of...
Topics
- 4-Nitroquinoline-1-oxide
- Culture Media
- DEAD-box RNA Helicases
- DNA Damage
- Genes, Fungal
- Genotype
- Methyl Methanesulfonate
- Mutation
- Plasmids
- Quinolones
- RNA Helicases
- Recombination, Genetic
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins