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Article

Variance-components methods for linkage and association analysis of ordinal traits in general pedigrees.

Genetic epidemiology - 1 Apr 2010

Diao G, Lin D Y

Abstract excerpt

Many complex human diseases such as alcoholism and cancer are rated on ordinal scales. Well-developed statistical methods for the genetic mapping of quantitative traits may not be appropriate for ordinal traits. We propose a class of variance-component models for the joint linkage and association analysis of ordinal traits. The proposed models accommodate arbitrary pedigrees and allow covariates and...

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PMID: 19918762
DOI: 10.1002/gepi.20453
PMCID: PMC3003595

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