Article
T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells.
The Journal of experimental medicine - 1 Sept 2008
Scheeren Ferenc A, Nagasawa Maho, Weijer Kees, Cupedo Tom, Kirberg Jörg, Legrand Nicolas, Spits Hergen
Abstract excerpt
IgM(+)IgD(+)CD27(+) B cells from peripheral blood have been described as circulating marginal zone B cells. It is still unknown when and where these cells develop. These IgM(+)IgD(+)CD27(+) B cells exhibit somatic hypermutations (SHMs) in their B cell receptors, but the exact nature of the signals leading to induction of these SHMs remains elusive. Here, we show that IgM(+)IgD(+)CD27(+) B cells carrying SHMs are...
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