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Article

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 2009

Wu Haiyan, Shekar S Chandra, Flinn Rory J, El-Sibai Mirvat, Jaiswal Bijay S, Sen K Ilker, Janakiraman Vasantharajan, Seshagiri Somasekar, Gerfen Gary J, Girvin Mark E, Backer Jonathan M

Abstract excerpt

We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110alpha requires (i) an inhibitory contact between the p85 nSH2 domain and the p110alpha helical domain, and (ii) a contact between the p85 nSH2 and iSH2 domains that orients the nSH2 so as to inhibit p110alph...

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Identifiers

PMID: 19915146
DOI: 10.1073/pnas.0902369106
PMCID: PMC2787125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19915146-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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