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Article

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.

The Journal of biological chemistry - 29 Jul 2005

Shekar S Chandra, Wu Haiyan, Fu Zheng, Yip Shu-Chin, Nagajyothi, Cahill Sean M, Girvin Mark E, Backer Jonathan M

Abstract excerpt

p85/p110 phosphoinositide 3-kinases regulate multiple cell functions and are frequently mutated in human cancer. The p85 regulatory subunit stabilizes and inhibits the p110 catalytic subunit. The minimal fragment of p85 capable of regulating p110 is the N-terminal SH2 domain linked to the coiled-coil iSH2 domain (referred to as p85ni). We have previously proposed that the conformationally rigid iSH2 domain...

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Identifiers

PMID: 15932879
DOI: 10.1074/jbc.M506005200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.PMID 15932879Read ↗

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