Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas.

Histopathology - 1 Nov 2009

Fu Xiangsheng, Li Jing, Li Kang, Tian Xiaoxiao, Zhang Yali

Abstract excerpt

AIMS: The role of Wnt signalling pathway in serrated adenomas (SAs) remains to be identified. The aim of this study was to determine whether Wnt signalling plays a role in the pathogenesis of SAs, and to clarify the mechanism of Wnt signalling activation in SAs. METHODS AND RESULTS: This study investigated immunoreactivities of adenomatous polyposis coli (APC) and beta-catenin, mutations of APC and beta-catenin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to beta Catenin
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Genes, APC

Share to Immunohistochemistry

Share to Microdissection

Share to Wnt Proteins

Source

Identifiers

PMID: 19912361
DOI: 10.1111/j.1365-2559.2009.03411.x

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas.PMID 19912361Read ↗

The role of APC in WNT pathway activation in serrated neoplasia.Semantic proximity Read ↗

Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum.Semantic proximity Read ↗

Prevalence and molecular characterisation of the sessile serrated adenoma in a subset of the Chinese population.Semantic proximity Read ↗

Infrequent APC mutations in serrated adenoma.Semantic proximity Read ↗

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.Semantic proximity Read ↗

Molecular characteristics of serrated adenomas of the colorectum.Semantic proximity Read ↗

Adenomatous polyposis coli alteration in digestive endocrine tumours: correlation with nuclear translocation of beta-catenin and chromosomal instability.Semantic proximity Read ↗

Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation.Semantic proximity Read ↗

Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonistsSemantic proximity Read ↗

CpG Island Methylation in Sessile Serrated Adenomas Increases With Age, Indicating Lower Risk of Malignancy in Young PatientsSemantic proximity Read ↗

The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma.Semantic proximity Read ↗

Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.