Article
The role of APC in WNT pathway activation in serrated neoplasia.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2018
Borowsky Jennifer, Dumenil Troy, Bettington Mark, Pearson Sally-Ann, Bond Catherine, Fennell Lochlan, Liu Cheng, McKeone Diane, Rosty Christophe, Brown Ian, Walker Neal, Leggett Barbara, Whitehall Vicki
Abstract excerpt
Conventional adenomas are initiated by APC gene mutation that activates the WNT signal. Serrated neoplasia is commonly initiated by BRAF or KRAS mutation. WNT pathway activation may also occur, however, to what extent this is owing to APC mutation is unknown. We examined aberrant nuclear β-catenin immunolocalization as a surrogate for WNT pathway activation and analyzed the entire APC gene coding sequence in...
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