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Article

Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.

Journal of the American Chemical Society - 9 Dec 2009

Acker Michael G, Bowers Albert A, Walsh Christopher T

Abstract excerpt

The thiocillins are natural-product antibiotics derived from ribosomally encoded peptides that undergo extensive posttranslational modifications to yield the mature trithiazolylpyridine-containing macrocyclic compound. Poor pharmacokinetic properties have prevented the clinical use of these highly potent antibiotics. Through in vivo manipulation of the gene responsible for production of the thiocillin precursor...

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Identifiers

PMID: 19911780
DOI: 10.1021/ja908777t
PMCID: PMC2787705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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