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Article

Ribosomal route to small-molecule diversity.

Journal of the American Chemical Society - 11 Jan 2012

Tianero Ma Diarey B, Donia Mohamed S, Young Travis S, Schultz Peter G, Schmidt Eric W

Abstract excerpt

The cyanobactin ribosomal peptide (RP) natural product pathway was manipulated to incorporate multiple tandem mutations and non-proteinogenic amino acids, using eight heterologous components simultaneously expressed in Escherichia coli . These studies reveal the potential of RPs for the rational synthesis of complex, new small molecules over multiple-step biosynthetic pathways using simple genetic engineering.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22107593
DOI: 10.1021/ja208278k
PMCID: PMC3268757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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