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Article

Recombinant Macrocyclic Lanthipeptides Incorporating Non-Canonical Amino Acids.

Journal of the American Chemical Society - 30 Aug 2017

Zambaldo Claudio, Luo Xiaozhou, Mehta Angad P, Schultz Peter G

Abstract excerpt

Nisin is a complex lanthipeptide that has broad spectrum antibacterial activity. In efforts to broaden the structural diversity of this ribosomally synthesized lantibiotic, we now report the recombinant expression of Nisin variants that incorporate noncanonical amino acids (ncAAs) at discrete positions. This is achieved by expressing the nisA structural gene, cyclase (nisC) and dehydratase (nisB), together with...

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Identifiers

PMID: 28809560
DOI: 10.1021/jacs.7b04159
PMCID: PMC5847277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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