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Article

Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.

Journal of the American Chemical Society - 27 Jun 2012

Bowers Albert A, Acker Michael G, Young Travis S, Walsh Christopher T

Abstract excerpt

The thiocillins from Bacillus cereus ATCC 14579 are natural products from the broader class of thiazolyl peptides. Their biosynthesis proceeds via extensive post-translational modification of a ribosomally encoded precursor peptide. This post-translational tailoring involves a key step formal cycloaddition between two distal serine residues. In the wild-type structure, this cycloaddition forms a major macrocycle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22686940
DOI: 10.1021/ja302820x
PMCID: PMC3387813

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