Article
Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2010
Coventry William L, James Michael R, Eaves Lindon J, Gordon Scott D, Gillespie Nathan A, Ryan Leanne, Heath Andrew C, Montgomery Grant W, Martin Nicholas G, Wray Naomi R
Abstract excerpt
The reported interaction between the length polymorphism (5HTTLPR) in the serotonin transporter gene (SLC6A4) and stressful life events on depression has led to many attempts to replicate but with inconsistent results. This inconsistency may reflect, in part, small sample size and the unknown contribution of the long allele SNP, rs25531. Using a large twin sample of 3,243 individuals from 2,230 families aged...
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