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Article

Impaired transmethylation potential in Parkinson's disease patients treated with L-Dopa.

Neuroscience letters - 14 Jan 2010

De Bonis Maria Luigia, Tessitore Alessandro, Pellecchia Maria Teresa, Longo Katia, Salvatore Anna, Russo Antonio, Ingrosso Diego, Zappia Vincenzo, Barone Paolo, Galletti Patrizia, Tedeschi Gioacchino

Abstract excerpt

Hyperhomocysteinaemia was reported in patients with Parkinson's disease (PD) treated with l-Dopa. The increase in plasma concentration of this sulfur compound arises from the massive methylation of the drug operated by the enzyme catechol-O-methyltransferase (COMT), which acts as a powerful sink of methyl groups. The contemporary occurrence of C677T polymorphism in homozygosity, leading to a temperature-labile...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19909787
DOI: 10.1016/j.neulet.2009.11.014

Genes

COMT
MTHFR

Variants

Provenance

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Related research

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Research trail→

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Impaired transmethylation potential in Parkinson's disease patients treated with L-Dopa.PMID 19909787Read ↗

Correlations Between Methionine Cycle Metabolism, COMT Genotype, and Polyneuropathy in L-Dopa Treated Parkinson's Disease: A Preliminary Cross-Sectional Study.Semantic proximity Read ↗

Role of Catechol-O-Methyltransferase (COMT)-Dependent Processes in Parkinson’s Disease and L-DOPA TreatmentSemantic proximity Read ↗

The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial.Semantic proximity Read ↗

Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.Semantic proximity Read ↗

Catechol-O-methyltransferase and Parkinson's disease.Semantic proximity Read ↗

Association of MTHFR C677T with total homocysteine plasma levels and susceptibility to Parkinson's disease: a meta-analysis.Semantic proximity Read ↗

Effect of acute hyperhomocysteinemia on methylation potential of erythrocytes and on DNA methylation of lymphocytes in healthy male volunteers.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.Semantic proximity Read ↗

The MTHFR C677T polymorphism modifies age at onset in Parkinson's disease.Semantic proximity Read ↗

G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms and plasma homocysteine in levodopa-treated and non-treated Parkinson's disease patients.Semantic proximity Read ↗

Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease.Semantic proximity Read ↗

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