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Article

The MTHFR C677T polymorphism modifies age at onset in Parkinson's disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Jan 2014

Vallelunga Annamaria, Pegoraro Valentina, Pilleri Manuela, Biundo Roberta, De Iuliis Angela, Marchetti Mauro, Facchini Silvia, Formento Dojot Patrizia, Antonini Angelo

Abstract excerpt

Hyperhomocysteinemia is a risk factor for Parkinson's disease (PD) and may result from genetic mutations or/and environmental factors. 5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia. In this study we analyzed whether two functional...

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Source

Identifiers

PMID: 24052451
DOI: 10.1007/s10072-013-1545-z

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The MTHFR C677T polymorphism modifies age at onset in Parkinson's disease.PMID 24052451Read ↗

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