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Article

Methylenetetrahydrofolate reductase polymorphisms and plasma homocysteine in levodopa-treated and non-treated Parkinson's disease patients.

Journal of the neurological sciences - 15 Dec 2009

Yuan Rey-Yue, Sheu Jau-Jiuan, Yu Jia-Ming, Hu Chaur-Jong, Tseng Ing-Jy, Ho Chun-Sum, Yeh Ching-Ying, Hung Ya-Lin, Chiang Tsuey-Ru

Abstract excerpt

Genetic C677T and A1298C polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) and levodopa therapy in Parkinson's disease (PD) may increase homocysteine (Hcy) level. We examined whether connecting both polymorphisms influences the effect of levodopa on Hcy. MTHFR genotypes and Hcy, vitamin B(12), and folate levels were determined in 48 levodopa-treated PD patients (PD-L), 28 non-treated PD patients...

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Identifiers

PMID: 19786283
DOI: 10.1016/j.jns.2009.09.007

Genes

MTHFR

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