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Article

Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Aug 2005

Tan Eng-King, Cheah Sin-Yun, Fook-Chong Stephanie, Yew Kenneth, Chandran V R, Lum Sau-Ying, Yi Zhao

Abstract excerpt

Pyridoxal-5-phosphate, the biological active form of pyridoxine, is a cofactor for dopa-decarboxylase (DDC) enzyme. Pyridoxine may augment the conversion of levodopa to dopamine in the periphery and therefore decrease availability of levodopa to the brain. However, this effect can be negated in t...

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Source

Identifiers

PMID: 15965967
DOI: 10.1002/ajmg.b.30198

Genes

COMT
DDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15965967-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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