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Article

Correlations Between Methionine Cycle Metabolism, COMT Genotype, and Polyneuropathy in L-Dopa Treated Parkinson's Disease: A Preliminary Cross-Sectional Study.

Journal of Parkinson's disease - 1 Jan 2017

Andréasson Mattias, Brodin Lovisa, Laffita-Mesa José Miguel, Svenningsson Per

Abstract excerpt

BACKGROUND: Polyneuropathy (pnp) is recognized as a clinical feature of Parkinson's disease (PD). Whether pnp is a result of the alpha-synucleinopathy or related to treatment is debated. Previous studies support underlying disturbances in the methionine cycle mediated by L-dopa. OBJECTIVE: Describe possible relationships between methionine cycle metabolism and the development of pnp in L-dopa treated PD....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28759974
DOI: 10.3233/JPD-171127

Genes

COMT

Variants

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