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Article

Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.

PloS one - 11 Nov 2009

Kuningas Maris, May Linda, Tamm Riin, van Bodegom David, van den Biggelaar Anita H J, Meij Johannes J, Frölich Marijke, Ziem Juventus B, Suchiman Helena E D, Metspalu Andres, Slagboom P Eline, Westendorp Rudi G J

Abstract excerpt

BACKGROUND: Chronic inflammation is involved in the pathogenesis of chronic age-associated, degenerative diseases. Pro-inflammatory host responses that are deleterious later in life may originate from evolutionary selection for genetic variation mediating resistance to infectious diseases under adverse environmental conditions. METHODOLOGY/PRINCIPAL FINDINGS: In the Upper-East region of Ghana where infection has...

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PMID: 19907653
DOI: 10.1371/journal.pone.0007795
PMCID: PMC2771352

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