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Article

Evolutionary adaptation of inflammatory immune responses in human beings.

Lancet (London, England) - 15 Jul 2000

Le Souëf P N, Goldblatt J, Lynch N R

Abstract excerpt

Modern man's ancestors lived in an environment where infectious, tropical diseases would have been endemic. We postulate that this relatively hostile environment would have caused genetic selection for increased proinflammatory immune responses. On migrating to temperate regions, pronounced proinflammatory responses would have been less important and selected against due to increased mortality from overly...

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PMID: 10963213
DOI: 10.1016/s0140-6736(00)02491-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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