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Article

Common CFTR gene variants influence body composition and survival in rural Ghana.

Human genetics - 1 Feb 2010

Kuningas Maris, van Bodegom David, May Linda, Meij Johannes J, Slagboom P Eline, Westendorp Rudi G J

Abstract excerpt

Various studies in mice have found support for the hypothesis that heterozygous carriers of cystic fibrosis transmembrane conductance regulator (CFTR) mutations have an increased resistance to fatal infection compared to both homozygous mutation carriers and non-carriers, while in humans such evidence is scarce. In this study, we assessed the CFTR heterozygotes survival advantage hypothesis in a contemporary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19890664
DOI: 10.1007/s00439-009-0762-2
PMCID: PMC2806536

Genes

CFTR

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