Article
Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation.
The Journal of biological chemistry - 21 Oct 2005
Kugimiya Fumitaka, Kawaguchi Hiroshi, Kamekura Satoru, Chikuda Hirotaka, Ohba Shinsuke, Yano Fumiko, Ogata Naoshi, Katagiri Takenobu, Harada Yoshifumi, Azuma Yoshiaki, Nakamura Kozo, Chung Ung-il
Abstract excerpt
Although accumulated evidence has shown the bone anabolic effects of bone morphogenetic proteins (BMPs) that were exogenously applied in vitro and in vivo, the roles of endogenous BMPs during bone formation remain to be clarified. This study initially investigated expression patterns of BMPs in the mouse long bone and found that BMP2 and BMP6 were the main subtypes expressed in hypertrophic chondrocytes that...
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