Article

Targeting EP2 receptor improves muscle and bone health in dystrophin<sup>-/-</sup>/utrophin<sup>-/-</sup> double knockout mice

2024-11-04

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a severe genetic muscle disease due to mutations of dystrophin gene. There is no cure for DMD. Using a dystrophin-/-utrophin-/- (DKO-Hom) mouse model, we investigated the PGE2/EP2 pathway in the pathogenesis of dystrophic muscle and its potential as a therapeutic target. We found that Ep2, Ep4, Cox-2, 15-Pgdh mRNA, and PGE2 are significantly increased in DKO-Hom mice compared t...

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Literature Corpus work: 25e97882-aa3c-5ff0-b8ab-dc5f24e9bc39
DOI: 10.20944/preprints202411.0141.v1

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