Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.

15 Dec 1993

Abstract excerpt

The major component of senile plaques found in the brains of Alzheimer disease patients is the beta-amyloid peptide, which is derived from a larger amyloid precursor protein (APP). Recently, a number of APP and APP-related proteins have been identified in different organisms and constitute the family of APP proteins. We have isolated several cDNAs encoding an APP-related protein in the nematode Caenorhabditis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 protein interactions
Share to Alzheimer's disease research and treatments
Share to Bioinformatics and Genomic Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8265668
DOI: 10.1073/pnas.90.24.12045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.PMID 8265668Read ↗

APL-1, a <i>Caenorhabditis elegans</i> protein related to the human β-amyloid precursor protein, is essential for viabilitySemantic proximity Read ↗

APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development.Semantic proximity Read ↗

AIP-1 ameliorates β-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease modelSemantic proximity Read ↗

The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans.Semantic proximity Read ↗

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.Semantic proximity Read ↗

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseasesSemantic proximity Read ↗

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.Semantic proximity Read ↗

feh-1 and apl-1, the Caenorhabditis elegansorthologues of mammalian Fe65 and β-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumpingSemantic proximity Read ↗

Ascidians: an invertebrate chordate model to study Alzheimer’s disease pathogenesisSemantic proximity Read ↗

Caenorhabditis elegans as a model organism to study APP functionSemantic proximity Read ↗

The Drosophila transcript encoded by the β-amyloid protein precursor-like gene is restricted to the nervous systemSemantic proximity Read ↗

Presence of a “CAGA box” in the APP gene unique to amyloid plaque‐forming species and absent in all APLP ‐1/2 genes: implications in Alzheimer's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.