Article
Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans.
The Journal of biological chemistry - 6 Aug 2010
Dejima Katsufumi, Murata Daisuke, Mizuguchi Souhei, Nomura Kazuko H, Izumikawa Tomomi, Kitagawa Hiroshi, Gengyo-Ando Keiko, Yoshina Sawako, Ichimiya Tomomi, Nishihara Shoko, Mitani Shohei, Nomura Kazuya
Abstract excerpt
Synthesis of extracellular sulfated molecules requires active 3'-phosphoadenosine 5'-phosphosulfate (PAPS). For sulfation to occur, PAPS must pass through the Golgi membrane, which is facilitated by Golgi-resident PAPS transporters. Caenorhabditis elegans PAPS transporters are encoded by two genes, pst-1 and pst-2. Using the yeast heterologous expression system, we characterized PST-1 and PST-2 as PAPS...
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