Article

Molecular Evolution of APP family proteins: Rapid Evolution of the Mammalian APLP1 as a Synaptic Adhesion Molecule

2021-03-05

Abstract excerpt

Amyloid precursor protein (APP) family members are involved in essential neuronal activities, and dysfunction of APP family members leads to neurodegenerative diseases such as Alzheimer’s disease. Among the APP gene family members, amyloid precursor-like protein 1 (APLP1) is selectively expressed in neurons and has specialized functions during synaptogenesis. Although a potential role for APLP1 in neuronal evoluti...

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Literature Corpus work: c42b1211-bba8-5456-9ec6-13d78f9726a7
DOI: 10.21203/rs.3.rs-267698/v1

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