Article
Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.
Biomolecules - 24 Apr 2020
Lillebostad Peder A G, Raasakka Arne, Hjellbrekke Silje J, Patil Sudarshan, Røstbø Trude, Hollås Hanne, Sakya Siri A, Szigetvari Peter D, Vedeler Anni, Kursula Petri
Abstract excerpt
The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long N-terminal region, which is predicted to be disordered, binds RNA, and forms membraneless organelles involved in neuronal transport. Mutations in AnxA11 have been linked to amyotrophic lateral...
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