Article

Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment

2020-03-27

Abstract excerpt

The functions of the annexin family of proteins involve binding to Ca 2+ , lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long N-terminal region, which is predicted to be disordered, binds RNA, and forms membraneless organelles involved in neuronal transport. Mutations in AnxA11 have been linked to amyotrophic lateral s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00fd49b4-f041-56b2-99b9-b33624c12434
DOI: 10.1101/2020.03.27.011445

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal SegmentDOI 10.1101/2020.03.27.011445Read

Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.Semantic proximity Read

Calcium as a molecular switch that regulates Annexin A11 N- and C-terminal domains interaction and its role in ALS.Semantic proximity Read

ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamics.Semantic proximity Read

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.Semantic proximity Read

Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair.Semantic proximity Read

Clinical and genetic characteristics of amyotrophic lateral sclerosis patients with ANXA11 variantsSemantic proximity Read

Genetic analysis of and clinical characteristics associated with ANXA11 variants in a Chinese cohort with amyotrophic lateral sclerosis.Semantic proximity Read

The crystal structure of annexin A8 is similar to that of annexin A3.Semantic proximity Read

Adult‐onset dominant muscular dystrophy in Greek families caused by Annexin A11Semantic proximity Read

Research Progress of Annexin A1 and Its Derived Peptides in The Diagnosis and Treatment of Circulatory DiseasesSemantic proximity Read

Comparative Genetics and Evolution of Annexin A13 as the Founder Gene of Vertebrate AnnexinsSemantic proximity Read

Annexin A11 mutations are associated with nuclear envelope dysfunction in vivo and in human tissues.Semantic proximity Read