Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients.

Carcinogenesis - 1 Feb 2013

Chen Jinyun, Pande Mala, Huang Yu-Jing, Wei Chongjuan, Amos Christopher I, Talseth-Palmer Bente A, Meldrum Cliff J, Chen Wei V, Gorlov Ivan P, Lynch Patrick M, Scott Rodney J, Frazier Marsha L

Abstract excerpt

Heterogeneity in age of onset of colorectal cancer in individuals with mutations in DNA mismatch repair genes (Lynch syndrome) suggests the influence of other lifestyle and genetic modifiers. We hypothesized that genes regulating the cell cycle influence the observed heterogeneity as cell cycle-related genes respond to DNA damage by arresting the cell cycle to provide time for repair and induce transcription of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Colorectal Neoplasms

Share to Follow-Up Studies

Share to Neoplasm Staging

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 23125224
DOI: 10.1093/carcin/bgs344
PMCID: PMC3564440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients.PMID 23125224Read ↗

Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome.Semantic proximity Read ↗

Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population.Semantic proximity Read ↗

MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Acceleration of the DNA methylation clock among lynch syndrome-associated mutation carriers.Semantic proximity Read ↗

DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.Semantic proximity Read ↗

Ovarian cancer at young age: the contribution of mismatch-repair defects in a population-based series of epithelial ovarian cancer before age 40Semantic proximity Read ↗

Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer.Semantic proximity Read ↗

Epigenetic drift association with cancer risk and survival, and modification by sexSemantic proximity Read ↗

Common risk variants for colorectal cancer: an evaluation of associations with age at cancer onset.Semantic proximity Read ↗

DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.Semantic proximity Read ↗

Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndrome.Semantic proximity Read ↗

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.