Article
Do the risks of Lynch syndrome-related cancers depend on the parent of origin of the mutation?
Familial cancer - 1 Jul 2020
Gemechu Shimelis Dejene, van Vliet Christine M, Win Aung Ko, Figueiredo Jane C, Le Marchand Loic, Gallinger Steven, Newcomb Polly A, Hopper John L, Lindor Noralane M, Jenkins Mark A, Dowty James G
Abstract excerpt
Individuals who carry pathogenic mutations in DNA mismatch repair (MMR) genes have high risks of cancer, and small studies have suggested that these risks depend on the sex of the parent from whom the mutation was inherited. We have conducted the first large study of such a parent-of-origin effect (POE). Our study was based on all MMR gene mutation carriers and their relatives in the Colon Cancer Family Registry,...
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