Article
Complex mitogenic requirements of Na(+)-K(+)-Cl(-)-cotransport-deficient BALB/c-3T3 cells.
Journal of cellular physiology - 1 Dec 1990
Smyth M J, O'Brien T G, Wharton W
Abstract excerpt
The ability of 12-O-tetradecanoylphorbol-13-acetate (TPA) to stimulate mitogenesis in BALB/c-3T3 cells and in a Na+K+Cl(-)-cotransport-defective variant subclone was investigated. This transport variant had previously been reported to be TPA mitogenically nonresponsive (O'Brien and Prettyman: Journal of Cellular Physiology 130:377-381, 1987) since the addition of TPA to the spent medium of density-arrested...
Topics
- Animals
- Carrier Proteins
- Cell Division
- Cell Line
- Clone Cells
- DNA Replication
- Genetic Variation
- Insulin
- Insulin-Like Growth Factor I
- Kinetics
- Mice
- Mice, Inbred BALB C