Article
APOE ε4 Carriers Have a Greater Propensity to Glycation and sRAGE Which Is Further Influenced by RAGE G82S Polymorphism.
The journals of gerontology. Series A, Biological sciences and medical sciences - 25 Sept 2020
Deo Permal, Dhillon Varinderpal S, Chua Ann, Thomas Philip, Fenech Michael
Abstract excerpt
APOE ε4 allele is an established risk factor for Alzheimer's disease and hypercholesterolemia. However, its association with metabolic and genetic risk factors related to glycation is not clear. We tested the hypothesis that, apart from high plasma cholesterol, APOE ε4 carriers may also have higher advanced glycation end products (AGEs) and total soluble extracellular domain of RAGE (sRAGE) and that these...
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