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Article

Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection.

Cell host & microbe - 13 Mar 2013

Das Suman R, Hensley Scott E, Ince William L, Brooke Christopher B, Subba Anju, Delboy Mark G, Russ Gustav, Gibbs James S, Bennink Jack R, Yewdell Jonathan W

Abstract excerpt

Human influenza A virus (IAV) vaccination is limited by "antigenic drift," rapid antibody-driven escape reflecting amino acid substitutions in the globular domain of hemagglutinin (HA), the viral attachment protein. To better understand drift, we used anti-hemagglutinin monoclonal Abs (mAbs) to sequentially select IAV escape mutants. Twelve selection steps, each resulting in a single amino acid substitution in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23498956
DOI: 10.1016/j.chom.2013.02.008
PMCID: PMC3747226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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