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Intrahepatic transcriptomics reveals gene signatures in chronic hepatitis B patients responded to interferon therapy

11 Jul 2022

Abstract excerpt

Chronic hepatitis B virus (HBV) infection remains a substantial public health burden worldwide. Alpha-interferon (IFNα) is one of the two currently approved therapies for chronic hepatitis B (CHB), to explore the mechanisms underlying IFNα treatment response, we investigated baseline and 24-week on-treatment intrahepatic gene expression profiles in 21 CHB patients by mRNA-seq. The data analyses demonstrated that...

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PMID: 35815389
DOI: 10.1080/22221751.2022.2100831

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