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Article

cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness.

PloS one - 1 Jan 2009

Langmesser Sonja, Franken Paul, Feil Susanne, Emmenegger Yann, Albrecht Urs, Feil Robert

Abstract excerpt

Many effects of nitric oxide (NO) are mediated by the activation of guanylyl cyclases and subsequent production of the second messenger cyclic guanosine-3',5'-monophosphate (cGMP). cGMP activates cGMP-dependent protein kinases (PRKGs), which can therefore be considered downstream effectors of NO signaling. Since NO is thought to be involved in the regulation of both sleep and circadian rhythms, we analyzed these...

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Identifiers

PMID: 19156199
DOI: 10.1371/journal.pone.0004238
PMCID: PMC2617781

Genes

PRKG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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