Article

Dose-dependent, opioid-induced sleep disruption is partially mediated by motor activity but not by body temperature in C57BL/6J mice

2025-06-27

Abstract excerpt

States of sleep and wakefulness, motor activity, and body temperature are temporally linked, yet these variables are often studied independently. Here we report novel results from male C57BL/6J mice (n = 24) that quantify the causal and correlational relationships between these temporally linked measures. The initial experiments used 12 mice to identify the lowest antinociceptive doses of fentanyl (0.1 mg/kg) and...

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Literature Corpus work: 1da58a0e-d18d-5509-871d-abcba258368f
DOI: 10.1101/2025.06.22.660933

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