Article
Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Dec 2009
Gruhn Bernd, Intek Juliane, Pfaffendorf Nadine, Zell Roland, Corbacioglu Selim, Zintl Felix, Beck James F, Debatin Klaus-Michael, Steinbach Daniel
Abstract excerpt
Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The selection of a suitable donor is the most critical issue in preventing severe GVHD. Recent data suggest that the risk of GVHD does not only depend on human leukocyte antigens (HLA) but also on polymorphisms of genes that influence immune responses. We analyzed the 1142 G>A...
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