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Article

Voltage-dependent anion channel (VDAC) is involved in apoptosis of cell lines carrying the mitochondrial DNA mutation.

BMC medical genetics - 9 Nov 2009

Yuqi Liu, Lei Gao, Yang Li, Zongbin Li, Hua Xu, Lin Wang, Rui Chen, Mohan Liu, Yi Wen, Minxin Guan, Shiwen Wang

Abstract excerpt

BACKGROUND: The mitochondrial voltage-dependent anion channel (VDAC) is increasingly implicated in the control of apoptosis. We have studied the effects the mitochondrial DNA (mtDNA) tRNAIle mutation on VDAC expression, localization, and apoptosis. METHODS: Lymphoblastoid cell lines were derived from 3 symptomatic and 1 asymptomatic members of a family with hypertension associated with the A4263G tRNAIle mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19895710
DOI: 10.1186/1471-2350-10-114
PMCID: PMC2779793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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